What SpO2 range is typically targeted for a non-COPD, spontaneously breathing patient?

• A. 90-95%
• B. 99-100%
• C. 88-92%
• D. 94-99%

Answer: (D)

Aim for a SpO2 that keeps tissues well oxygenated without exposing the patient to excess oxygen. In adults who are spontaneously breathing and do not have COPD, the safest and most practical target is the mid-to-upper 90s, roughly 94–99%. This range corresponds to adequate arterial oxygen (PaO2 around the normal to high end) while avoiding hyperoxia that can lead to oxygen toxicity and related issues with prolonged high FiO2. Values in the low 90s or below can risk hypoxemia, while aiming for 99–100% offers little additional benefit and increases the chance of oxygen-related harm. The lower ranges (like 88–92%) are typically reserved for COPD patients who may tolerate higher oxygen levels poorly due to CO2 retention.